The importance of neopterin in COVID-19: The prognostic value and relation with the disease severity

Rasmi Y., Heidari N., Kübra Kırboğa K. K., Hatamkhani S., Tekin B., Alipour S., ...More

Clinical Biochemistry, vol.104, pp.1-12, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 104
  • Publication Date: 2022
  • Doi Number: 10.1016/j.clinbiochem.2022.03.002
  • Journal Name: Clinical Biochemistry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.1-12
  • Keywords: COVID-19, Neopterin, Prognosis, SARS CoV-2
  • Bilecik Şeyh Edebali University Affiliated: Yes

Abstract

Coronavirus Disease 2019 [COVID-19], caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2], has rapidly evolved into a global health emergency. Neopterin [NPT], produced by macrophages when stimulated with interferon [IFN-]gamma, is an essential cytokine in the antiviral immune response. NPT has been used as a marker for the early assessment of disease severity in different diseases. The leading cause of NPT production is the pro-inflammatory cytokine IFN-. Macrophage activation has also been revealed to be linked with disease severity in SARS-CoV-2 patients. We demonstrate the importance of NPT in the pathogenesis of SARS-CoV-2 and suggest that targeting NPT in SARS-CoV-2 infection may be critical in the early prediction of disease progression and provision of timely management of infected individuals.