Polyamines as quality control metabolites operating at the post-transcriptional level

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Poidevin L., ÜNAL D., Belda-Palazón B., Ferrando A.

Plants, cilt.8, sa.4, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8 Sayı: 4
  • Basım Tarihi: 2019
  • Doi Numarası: 10.3390/plants8040109
  • Dergi Adı: Plants
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: No-go decay, Non-stop decay, Nonsense-mediated decay, Polyamines, Quality control, Spermidine, Thermospermine, Translation
  • Bilecik Şeyh Edebali Üniversitesi Adresli: Evet

Özet

© 2019 by the authors. Licensee MDPI, Basel, Switzerland.Plant polyamines (PAs) have been assigned a large number of physiological functions with unknown molecular mechanisms in many cases. Among the most abundant and studied polyamines, two of them, namely spermidine (Spd) and thermospermine (Tspm), share some molecular functions related to quality control pathways for tightly regulated mRNAs at the level of translation. In this review, we focus on the roles of Tspm and Spd to facilitate the translation of mRNAs containing upstream ORFs (uORFs), premature stop codons, and ribosome stalling sequences that may block translation, thus preventing their degradation by quality control mechanisms such as the nonsense-mediated decay pathway and possible interactions with other mRNA quality surveillance pathways.