Novel tetrazole derivatives: synthesis, anticholinesterase activity and cytotoxicity evaluation
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.42, sa.2, ss.169-180, 2017 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 42 Sayı: 2
- Basım Tarihi: 2017
- Doi Numarası: 10.1515/tjb-2016-0207
- Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.169-180
- Anahtar Kelimeler: Tetrazole, Hydrazone, Anticholinesterase, AChE, BuChE, Cytotoxicity, ACETYLCHOLINESTERASE INHIBITORS, CHOLINESTERASE-INHIBITORS, BIOLOGICAL-ACTIVITIES, ALZHEIMERS-DISEASE, DESIGN, CHEMISTRY, SUGARS, MOIETY
- Bilecik Şeyh Edebali Üniversitesi Adresli: Hayır
Özet
Objective(s): The synthesis of new N'-arylidene-4-[(1phenyl- 1H-tetrazole-5-yl) thio] butanoylhydrazide derivatives (1-26) and investigation of their potential anticholinesterase (AChE), butyrylcholinesterase (BuChE) enzyme inhibition activities and also cytotoxic properties on mouse embryonic fibroblast cells (NIH/3T3) were aimed in this work.