Preparation of Responsive Zwitterionic Diblock Copolymers Containing Phosphate and Phosphonate Groups
Macromolecular Research, vol.28, no.12, pp.1134-1141, 2020 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 28 Issue: 12
- Publication Date: 2020
- Doi Number: 10.1007/s13233-020-8148-3
- Journal Name: Macromolecular Research
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Compendex, INSPEC
- Page Numbers: pp.1134-1141
- Keywords: diblock copolymer, micelles, nanoparticles, pH-responsive polymer, phosphorus-based polymers, self-assembly, temperature-responsive polymer, zwitterionic polymers
- Bilecik Şeyh Edebali University Affiliated: Yes
Abstract
© 2020, The Polymer Society of Korea and Springer.In this study, novel zwitterionic diblock copolymers, namely poly(2-(N-morpholino)ethyl methacrylate))-block-poly(2-(methacryloyloxy)ethyl phosphate) (PMEMA-b-PMOEP) and poly(2-(N-morpholino)ethyl methacrylate))-block-poly ((methacryloyloxy)methyl phosphonic acid) (PMEMA-b-PMOMP), were synthesized via reversible addition-fragmentation chain transfer controlled radical polymerization. Solution properties of these phosphorus-based diblock copolymers were investigated using dynamic light scattering, transmission electron microscopy and proton nuclear magnetic resonance spectroscopy. Since the PMEMA block has both salt- and thermo-responsive properties, PMEMA-b-PMOEP and PMEMA-b-PMOMP diblock copolymers formed core-shell micelles in basic aqueous media as the PMEMA block formed insoluble micelle core with the addition of Na2SO4 or an increase in temperature in basic solution. Additionally, PMEMA-b-PMOMP diblock copolymers interacted strongly with calcium cations and yielded reverse micellar structures via complexation of phosphate with metal cation in aqueous media.[Figure not available: see fulltext.].