Akademik Veri Yönetim Sistemi
Turkish Journal of Biochemistry, cilt.43, sa.3, ss.220-227, 2018 (SCI-Expanded)
Objective: The advent of resistant pathogenic microorganisms against current antimicrobial drugs prompted scientists to investigate novel molecules with new mechanisms. In this paper, some new 2-[2-[4-(ethyl/phenyl)cyclohex-ylidene]hydrazinyl]-4-(4-substitutedphenyl)thiazole (2a-2o) derivatives were synthesized and studied for their antimicrobial activities. Materials and methods: The title compounds (2a-2o) were obtained via the reaction of 4-(ethyl/phenyl)cyclohexane-1-one with appropriate phenacyl bromide in ethanol at room temperature. The chemical structures of the compounds were elucidated by FT-IR, 1H-NMR, 13C-NMR, HRMS and elemental analysis. Antimicrobial activity of the compounds was measured by using broth microdilution method. Chloramphenicol and ketoconazole were used as reference drugs. Results: Among the synthesized compounds, 2-[2-(4-phe-nylcyclohexylidene)hydrazinyl]-4-phenylthiazole (2h) and 2-[2-(4-phenylcyclohexylidene)hydrazinyl]-4-(4-chlo-rophenyl)thiazole (2l) have been found to exhibit potency almost four-fold better than ketoconazole against C. albicans with MIC90 value of 1.95. Conclusion: The current study contributed to the knowledge of the antimicrobial activity of thiazole bearing compounds.