Synthesis and antinociceptive activities of some pyrazoline derivatives

KAPLANCIKLI Z. A., Turan-Zitouni G., ÖZDEMİR A., CAN Ö. D., Chevallet P.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol.44, no.6, pp.2606-2610, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 6
  • Publication Date: 2009
  • Doi Number: 10.1016/j.ejmech.2008.09.002
  • Journal Name: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
  • Page Numbers: pp.2606-2610
  • Keywords: Pyrazoline, Benzoxazole, Benzimidazole, Hot plate, Writhing test, Rota-Rod, NITRIC-OXIDE SYNTHASE, PHARMACOLOGICAL-PROPERTIES, ANTIINFLAMMATORY AGENTS, MICE, CYCLOOXYGENASE-2, INHIBITION, EXTRACT, POTENT, BASES, ACID
  • Bilecik Şeyh Edebali University Affiliated: No

Abstract

In the present study, some pyrazoline derivatives were synthesized to investigate their potential antinociceptive activities. 1-[(Benzoxazole/benzimidazole-2-yl)thioacetyl]pyrazoline derivatives were obtained by reacting 3,5-diaryl-1-(2-chloroacetyl)pyrazolines with 2-marcaptobenzoxazole/benzimidazole. The chemical structures of the compounds were elucidated by IR, H-1 NMR and FAB(+)-MS spectral data and Elemental Analyses.