Akademik Veri Yönetim Sistemi
12. ULUSLARARASI ZEUGMA BİLİMSEL ARAŞTIRMALAR KONGRESİ, Gaziantep, Türkiye, 2 - 04 Ekim 2024, ss.8-9
The most valid diagnostic method to distinguish hypoproductive (e.g. AML, ALL, MDS) and hyperdestructive thrombocytopenia (e.g. ITP) is bone marrow examination. However, bone marrow examination is a highly invasive method and is not recommended in some studies for the diagnosis of hyperdestructive thrombocytopenia such as ITP. In some studies conducted in recent years, it has been suggested that platelet parameters such as Platelet Test (PCT) can be used in the differential diagnosis of thrombocytopenia. Plateletcrit is the ratio of the volume formed by platelets to the total blood volume. Our aim in this study was to investigate the effectiveness of these parameters in the differential diagnosis of thrombocytopenia.
Our study included 20 Idiopathic Thrombocytopenic Purpura (ITP), 10 acute myeloid leukemia (AML), 2 acute lymphoblastic leukemia (ALL), and 7 myelodysplastic syndrome (MDS) patients who were followed up in the Hematology outpatient clinic. ITP patients were classified as hyperdestructive group (20 patients) and the others were classified as hypoproductive group (19 patients). Blood samples were taken from the patients at the time of diagnosis and their hemogram and platelet parameters were automatically determined on the Beckman-Coulter device.
There was no difference between the two groups in terms of gender and age (p>0.05). Serum hemoglobin and white blood cell levels were found to be lower in the hypoproductive group than in the other group (p<0.001). There was no difference between the two groups in terms of platelet count (p = 0.444). PCT value was lower in the hyperdestructive group (p<0.039). In this study, it was determined that PCT, one of the platelet parameters, is a very easy, cheap and safe method to evaluate in the differential diagnosis of thrombocytopenia.