Possible role of Mycobacterium tuberculosis complex in Melkersson-Rosenthal syndrome demonstrated with Gen-Probe amplified Mycobacterium tuberculosis direct test
Australasian Journal of Dermatology, cilt.45, sa.2, ss.94-99, 2004 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 45 Sayı: 2
- Basım Tarihi: 2004
- Doi Numarası: 10.1111/j.1440-0960.2004.00071.x
- Dergi Adı: Australasian Journal of Dermatology
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.94-99
- Anahtar Kelimeler: Aetiology, Granulomatous cheilitis, Lingua plicata
- Bilecik Şeyh Edebali Üniversitesi Adresli: Hayır
Özet
Melkersson-Rosenthal (MRS) syndrome is characterized by a classical triad of recurrent or persistent orofacial swelling, peripheral facial nerve paralysis and lingua plicata. Granulomatous cheilitis (GC) is regarded as a monosymptomatic form of MRS. The exact aetiologies or MRS and GC are unknown. In this study we investigated the possible role of mycobacteria in these two conditions. A ribosomal RNA amplification-based Gen-Probe amplified Mycobacterium tuberculosis direct test was used to investigate the presence of M. tuberculosis complex in paraffin-embedded skin biopsy specimens from five patients with MRS and one patient with GC. Three of the six specimens were shown to be positive using this system; one of the positive specimens also showed positive Ziehl-Neelsen staining. These results suggest a possible mycobacterial aetiology for MRS and GC.