Possible role of Mycobacterium tuberculosis complex in Melkersson-Rosenthal syndrome demonstrated with Gen-Probe amplified Mycobacterium tuberculosis direct test

Apaydin R., Bahadir S., Kakklikkaya N., Bilen N., BAYRAMGÜRLER D.

Australasian Journal of Dermatology, cilt.45, sa.2, ss.94-99, 2004 (Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 2
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1111/j.1440-0960.2004.00071.x
  • Dergi Adı: Australasian Journal of Dermatology
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.94-99
  • Anahtar Kelimeler: Aetiology, Granulomatous cheilitis, Lingua plicata
  • Bilecik Şeyh Edebali Üniversitesi Adresli: Hayır

Özet

Melkersson-Rosenthal (MRS) syndrome is characterized by a classical triad of recurrent or persistent orofacial swelling, peripheral facial nerve paralysis and lingua plicata. Granulomatous cheilitis (GC) is regarded as a monosymptomatic form of MRS. The exact aetiologies or MRS and GC are unknown. In this study we investigated the possible role of mycobacteria in these two conditions. A ribosomal RNA amplification-based Gen-Probe amplified Mycobacterium tuberculosis direct test was used to investigate the presence of M. tuberculosis complex in paraffin-embedded skin biopsy specimens from five patients with MRS and one patient with GC. Three of the six specimens were shown to be positive using this system; one of the positive specimens also showed positive Ziehl-Neelsen staining. These results suggest a possible mycobacterial aetiology for MRS and GC.