Seizures after overdoses of bupropion intake

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Kara H., Ak A., Bayir A., Acar D., Istanbulluoǧlu R., DEĞİRMENCİ S.

Balkan Medical Journal, cilt.30, sa.2, ss.248-249, 2013 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 2
  • Basım Tarihi: 2013
  • Doi Numarası: 10.5152/balkanmedj.2012.094
  • Dergi Adı: Balkan Medical Journal
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.248-249
  • Anahtar Kelimeler: Bupropion, Overdoses, Seizures
  • Bilecik Şeyh Edebali Üniversitesi Adresli: Hayır

Özet

Background: Bupropion is a new-generation monocyclic antidepressant that has been accidentally found to have potential effects on reducing nicotine addiction. It is structurally similar to stimulants such as amphetamine and inhibits dopamine and noradrenalin reuptake selectively. Case Reports: We report two cases with no history of epilepsy who took oral bupropion for depression and had generalised tonic-clonic type of seizures in their follow-ups. Conclusion: After an overdose of bupropion, clinical effects are seen primarily on the neurological, cardiovascular, and gastrointestinal systems. Neurological effects can include tremor, confusion, agitation, hallucinations, coma, and seizures. © Trakya University Faculty of Medicine.