TPH1 (tryptophan hydroxylase 1)
Atlas of Genetics and Cytogenetics in Oncology and Haematology, vol.24, no.11, pp.414-423, 2020 (Scopus)
- Publication Type: Article / Review
- Volume: 24 Issue: 11
- Publication Date: 2020
- Doi Number: 10.4267/2042/70861
- Journal Name: Atlas of Genetics and Cytogenetics in Oncology and Haematology
- Journal Indexes: Scopus, EMBASE
- Page Numbers: pp.414-423
- Keywords: Alzheimer's Disease, Bipolar disorder, Inflammation, Intestine, Schizophrenia, Serotonin, Suicide, Tryptophan hydroxylase 1
- Bilecik Şeyh Edebali University Affiliated: No
Abstract
© 2020. Atlas of Genetics and Cytogenetics in Oncology and HaematologyTryptophan hydroxylase 1 gene (TPH1) encodes a rate-limiting enzyme in the biosynthesis of the monoamine neurotransmitter serotonin. TPH1 is expressed in peripheral tissues such as the heart, lung, kidney, duodenum and adrenal gland, as well as in female reproductive tissues. The mutations in this gene have been associated with various diseases with high risk, including, schizophrenia, somatic anxiety, anger-related features, bipolar disorder, suicidal behavior, and several addictions.