Studies on hydrazone derivatives as antifungal agents

ÖZDEMİR A., Turan-Zitouni G., KAPLANCIKLI Z. A., DEMİRCİ F., İŞCAN G.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol.23, no.4, pp.470-475, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 4
  • Publication Date: 2008
  • Doi Number: 10.1080/14756360701709094
  • Journal Name: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.470-475
  • Keywords: thiazolylhydrazone, antifungal activity, Candida spp., ANTIMICROBIAL ACTIVITY, CANDIDA-ALBICANS, ANTIBACTERIAL, INHIBITORS, DESIGN
  • Bilecik Şeyh Edebali University Affiliated: No

Abstract

The increasing clinical importance of drug-resistant fungal pathogens has urged additional need to fungal research and new antifungal compound development. For this purpose, some N-(1-benzyl-2-phenylethylidene)-N'-[4-(aryl)thiazol-2-yl]hydrazone (1a-e) and N-(1-phenylbutylidene)-N'-[4-(aryl)thiazol-2-yl]hydrazone (2a-e) derivatives were synthesised and evaluated for antifungal activity. Their antifungal activities against standard and clinical strands of Candida albicans, Candida glabrata, Candida utilis, Candida tropicalis, Candida krusei, Candida zeylanoides, and Candida parapsilosis were investigated. A significant level of activity was observed.