Synthesis and biological activities of new hydrazide derivatives

Oezdemir A., Turan-Zitouni G., KAPLANCIKLI Z. A., TUNALI Y.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, cilt.24, sa.3, ss.825-831, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 3
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1080/14756360802399712
  • Dergi Adı: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.825-831
  • Anahtar Kelimeler: Hydrazide, imidazo[1,2-a]pyrazine, antimicrobial activity, antituberculosis activity, MYCOBACTERIUM-TUBERCULOSIS, ANTIMICROBIAL ACTIVITY, IMIDAZO<1,2-A>PYRAZINE DERIVATIVES, HETEROCYCLIC-COMPOUNDS, IN-VITRO, HYDRAZONES, CYTOCHROME-P450, AGENTS, ACID, INFECTION
  • Bilecik Şeyh Edebali Üniversitesi Adresli: Hayır

Özet

The synthesis of a new series of imidazo[1,2-a]pyrazine-2-carboxylic acid arylidene-hydrazides is described. The chemical structures of the compounds were elucidated by IR, H-1-NMR, FAB(+)-MS spectral data. Their biological activity against various bacteria, fungi species, and Mycobacterium tuberculosis was investigated. Antibacterial activity was measured against Escherichia coli (NRRL B-3704), Staphylococcus aureus (NRRL B-767), Salmonella typhimurium (NRRL B-4420), Proteus vulgaris (NRLL B-123), Enterococcus faecalis (isolated obtained from Faculty of Medicine Osmangazi University, Eskisehir, Turkey), Pseudomonas aeruginosa (NRRL B-23 27853), Klebsiella spp. (isolated obtained from Faculty of Medicine Osmangazi University, Eskisehir, Turkey), while antifungal activity was evaluated against Candida albicans (isolates obtained from Osmangazi Uni. Fac. of Medicine), Candida glabrata (isolates obtained from Osmangazi Uni. Fac. of Medicine). Compounds were also evaluated for antituberculosis activity against Mycobacterium tuberculosis H(37)Rv using the BACTEC 460 radiometric system and BACTEC 12B medium. The compounds showed moderate inhibitor effects against human pathogenic microorganisms., whereas the preliminary results indicated that all of the tested compounds were inactive against Mycobacterium tuberculosis H(37)Rv.