Akademik Veri Yönetim Sistemi
JOURNAL OF CHEMISTRY, cilt.2016, 2016 (SCI-Expanded)
Some hydrazone derivatives were synthesized and their potential anticholinesterase activities were examined. A series of eleven new compounds of N'-(2,4-disubstitutedbenzylidene)-2-(4-(4-nitrophenyl)piperazin-1-yl)acetohydrazide derivatives were obtained via reaction of 2-[4-(4-nitrophenyl)piperazin-1-yl]acetohydrazide with aromatic aldehydes. The chemical structures of the compounds were enlightened by FT-IR, H-1-NMR, C-13-NMR, and HRMS (ESI) spectral data. The inhibition potency of the compounds 3a-k against AChE and BuChE was measured and evaluated using a modification of Ellman's spectrophotometric method. Among the tested compounds, compound 3c was assigned to be the most active derivative. Galantamine was used as a standard drug .