Preparation of some pyrazoline derivatives and evaluation of their antifungal activities

ÖZDEMİR A., Turan-Zitouni G., KAPLANCIKLI Z. A., Revial G., DEMİRCİ F., Iscan G.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, cilt.25, sa.4, ss.565-571, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 4
  • Basım Tarihi: 2010
  • Doi Numarası: 10.3109/14756360903373368
  • Dergi Adı: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.565-571
  • Anahtar Kelimeler: Pyrazoline, antifungal activity, Candida spp., ANTIMICROBIAL ACTIVITIES, THIABENDAZOLE, ANTIBACTERIAL
  • Bilecik Şeyh Edebali Üniversitesi Adresli: Hayır

Özet

The synthesis of a new series of 1-[( benzazole-2-yl)thioacetyl]-3,5-diaryl-2-pyrazoline derivatives was obtained by reacting 1-( chloroacetyl)-3,5-diaryl-pyrazolines with 2-mercaptobenzimidazole/benzoxazole/benzothiazole. The chemical structures of the compounds were elucidated by (1)H-NMR, (13)C-NMR, and FAB(+)-MS spectral data. Their antifungal activities against Candida albicans, Candida glabrata, Candida utilis, Candida tropicalis, Candida krusei, and Candida parapsilosis were investigated. A significant level of activity was observed.