HTR4 (5-hydroxytryptamine receptor 4)

GURBANOV R., Karadag H.

Atlas of Genetics and Cytogenetics in Oncology and Haematology, cilt.24, sa.6, ss.224-233, 2020 (Scopus) identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 24 Sayı: 6
  • Basım Tarihi: 2020
  • Doi Numarası: 10.4267/2042/70748
  • Dergi Adı: Atlas of Genetics and Cytogenetics in Oncology and Haematology
  • Derginin Tarandığı İndeksler: Scopus, EMBASE
  • Sayfa Sayıları: ss.224-233
  • Anahtar Kelimeler: 5-hydroxytryptamine receptor 4, Alzheimer's Disease, Central Nervous System (CNS), Inflammatory Bowel Disease (IBD), Obesity., Serotonin (5-HT)
  • Bilecik Şeyh Edebali Üniversitesi Adresli: Evet

Özet

© 2020 Atlas of Genetics and Cytogenetics in Oncology and Haematology.Being a member of the serotonin receptor family, 5-HT4 receptor ties up the neurotransmitter-serotonin (5-hydroxytryptamine/ 5-HT) in the central nervous system (CNS) of mammals. Commonly 5-HT4 receptors (5-HTR4) are G-protein-coupled receptors (GPCRs), in which the G proteins cause the induction of adenylate cyclase, subsequently leading to cyclic adenosine monophosphate (cAMP) and protein kinase A (PKA) activations. These receptors are commonly expressed in gastrointestinal, cardiovascular, nervous, and urinary systems, as well as the adrenal cortex (Tack et al., 2012). In this review article, the genetic, cellular, and biochemical knowledge of 5-HT4 receptors is deliberated. Besides the emphasis on receptor-ligand interaction with therapeutics, the implication of these receptors in several health disturbances/diseases is considered on the basis of available literature.