Fighting Against Alzheimer's Disease: Synthesis of New Pyrazoline and Benzothiazole Derivatives as New Acetylcholinesterase and MAO Inhibitors

Turan-Zitouni G., Hussein W., SAĞLIK B. N., BAYSAL M., KAPLANCIKLI Z. A.

LETTERS IN DRUG DESIGN & DISCOVERY, vol.15, no.4, pp.414-427, 2018 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 4
  • Publication Date: 2018
  • Doi Number: 10.2174/1570180814666170704144917
  • Journal Name: LETTERS IN DRUG DESIGN & DISCOVERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.414-427
  • Keywords: Thiophene, 3-phenyl-2-pyrazoline, benzothiazole, acetylcholinesterase, Monoamine oxidase (MAO), MAO inhibitors, Alzheimer's disease, molecular docking, MONOAMINE-OXIDASE, BIOLOGICAL EVALUATION, COGNITIVE DYSFUNCTION, DESIGN
  • Bilecik Şeyh Edebali University Affiliated: No

Abstract

Background: Alzheimer's Disease (AD) is a complicated neurodegenerative disorder with a multifaceted pathogenesis. AD, characterized by gradual memory loss, falling in language ability and other cognitive deterioration, and has been a prominent risk to ageing population. This means that there is an urgent need to find new lead compounds for controlling and fighting against (AD). In this way, a new thiophene-2-pyrazoline derivatives (A1-A5) and benzothiazole derivatives (A6-A13) have been synthesized to give beneficial compounds to controlling and battling against (AD).