Fighting Against Alzheimer's Disease: Synthesis of New Pyrazoline and Benzothiazole Derivatives as New Acetylcholinesterase and MAO Inhibitors
LETTERS IN DRUG DESIGN & DISCOVERY, cilt.15, sa.4, ss.414-427, 2018 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 15 Sayı: 4
- Basım Tarihi: 2018
- Doi Numarası: 10.2174/1570180814666170704144917
- Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.414-427
- Anahtar Kelimeler: Thiophene, 3-phenyl-2-pyrazoline, benzothiazole, acetylcholinesterase, Monoamine oxidase (MAO), MAO inhibitors, Alzheimer's disease, molecular docking, MONOAMINE-OXIDASE, BIOLOGICAL EVALUATION, COGNITIVE DYSFUNCTION, DESIGN
- Bilecik Şeyh Edebali Üniversitesi Adresli: Hayır
Özet
Background: Alzheimer's Disease (AD) is a complicated neurodegenerative disorder with a multifaceted pathogenesis. AD, characterized by gradual memory loss, falling in language ability and other cognitive deterioration, and has been a prominent risk to ageing population. This means that there is an urgent need to find new lead compounds for controlling and fighting against (AD). In this way, a new thiophene-2-pyrazoline derivatives (A1-A5) and benzothiazole derivatives (A6-A13) have been synthesized to give beneficial compounds to controlling and battling against (AD).