Studies of Glutathione Reductase Inhibitors Activity of Copper(II) Complexes

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TUNÇ T.

Bilecik Şeyh Edebali Üniversitesi Fen Bilimleri Dergisi, vol.6, no.1a, pp.117-122, 2019 (Peer-Reviewed Journal) identifier

Abstract

(S)-(+) - phenylglycinol, (1S, 2R)-2-amino-1, 2-diphenylethanol and (R)-(+)-2-amino-1, 1, 3- triphenylpropanol based chiral copper (II) complex of Schiff bases were synthesized. The effects of these compounds on glutathione reductase enzyme were investigated. The best inhibitory effect was found to belong to complex 3.
(S)-(+)-fenilglisinol, (1S, 2R) -2-amino-1,2-difeniletanol’in ve (R)-(+)-2-amino-1,1,3-trifenilpropanol bazlıkiral Schiff bazlarının bakır (II) kompleksi sentezlendi. Bu bileşiklerin glutatyon redüktaz enzimi üzerindekietkileri incelendi. En iyi inhibitör etkisinin kompleks 3'e ait olduğu belirlenmiştir.