Synthesis of novel thiazolylpyrazoline derivatives and evaluation of their antimicrobial activities and cytotoxicities

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Tabbi A., KAPLANCIKLI Z. A., Tebbani D., YURTTAŞ L., CANTÜRK Z., ATLI EKLİOĞLU Ö., ...More

TURKISH JOURNAL OF CHEMISTRY, vol.40, no.4, pp.641-654, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 4
  • Publication Date: 2016
  • Doi Number: 10.3906/kim-1512-12
  • Journal Name: TURKISH JOURNAL OF CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.641-654
  • Keywords: 2-Pyrazoline, thiazole, thiazolylpyrazoline, antimicrobial activity, cytotoxicity, THIAZOLYL-PYRAZOLINE DERIVATIVES, POTENTIAL ANTICANCER AGENTS, MOLECULAR DOCKING, ANTIFUNGAL ACTIVITIES, INHIBITORS, BENZODIOXOLE, DISCOVERY, THIOPHENE
  • Bilecik Şeyh Edebali University Affiliated: No

Abstract

Several novel thiazolylpyrazoline derivatives were synthesized by reacting substituted 3,5-diaryl-1-thiocarbamoyl-2-pyrazolines with phenacylbromides. The structures of the synthesized compounds were confirmed by IR, H-1 NMR, C-13 NMR, and MS spectral data. Their antimicrobial activities against Staphylococcus Atreus (ATCC-25923), Enterococcus faecalis (ATCC-29212), Enterococcus faecalis (ATCC-51922), Listeria monocytogenes (ATCC-1911), Klebsiella pneumoniae (ATCC-700603), Pseudomonas aeruginosa (ATCC-27853), Escherichia coli (ATCC-35218), Escherichia coli (ATCC-25922), Candida albicans (ATCC-90028), Candida glabrata (ATCC-90030), Candida krusei (ATCC-6258), and Candida parapsilosis (ATCC-22019) were investigated. The compounds were also studied for their cytotoxic effects using a MIT assay. Compound 7c showed the highest antimicrobial activity, possessing the same potential as chloramphenicol against K. pneumonia, P. aeruginosa, and E. coli (ATCC-25923).