Multiwalled Carbon Nanotubes-Chitosan Modified Single-Use Biosensors for Electrochemical Monitoring of Drug-DNA Interactions

Sengiz C., Çongur G., Eksin E., Erdem A.

Electroanalysis, cilt.27, sa.8, ss.1855-1863, 2015 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 8
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1002/elan.201500107
  • Dergi Adı: Electroanalysis
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1855-1863
  • Anahtar Kelimeler: Chitosan, Drug-DNA interactions, Electrochemical biosensors, Mitomycin C, Multiwalled carbon nanotubes
  • Bilecik Şeyh Edebali Üniversitesi Adresli: Evet

Özet

A multiwalled carbon nanotubes (CNT)-chitosan (CHIT) modified pencil graphite electrode (CNT-CHIT/PGE) was developed for the first time herein for electrochemical monitoring of the interaction of an anticancer drug, mitomycin C (MC) and DNA. The characterization of unmodified PGE, CHIT/PGE, CNT/PGE and CHIT-CNT/PGE were performed by scanning electron microscopy and cyclic voltammetry techniques. The oxidation signals of MC and guanine were measured before and after interaction at the surface of CNT-CHIT/PGEs using differential pulse voltammetry. Electrochemical impedance spectroscopy technique was also successfully utilized for monitoring of the interaction process at the surface of CNT-CHIT/PGEs in different interaction times.