Akademik Veri Yönetim Sistemi
Farmacia, cilt.73, sa.5, ss.1275-1283, 2025 (SCI-Expanded, Scopus)
Duchenne muscular dystrophy (DMD) is a muscle weakness disease characterised by dystrophin deficiency. Since dystrophin is found in all muscle types, it affects different organs, especially the digestive system. Our study aims to define the enteropathy associated with dystrophin deficiency at the levels of klotho, mTOR, apoptosis and cytokines. In our study, wild-type mice and D2-mdx mice were evaluated (n = 10). Elisa, RT-PCR, western blot (WB), histochemistry and immunohistochemistry (IHC) tests were performed on intestinal tissue. Enteropathy associated with dystrophin deficiency was seen in D2-mdx mice. Intestinal mucus, wall and villus thickness show a decrease in D2-mdx mice. Klotho, mTOR levels are highly suppressed, while IL-6, Caspase 3 and 8 levels show an increase. BAX and Bcl-2 levels in WB show increased oxidative stress in correlation with TOS, LDH and Galanin levels. Gastroenteritis in DMD is linked to the dystrophin complex. Dystrophin deficiency leads to decreased motility and increased oxidative stress levels. This results in changes in IL levels. The rise in inflammation has a surprising impact on Klotho and Galanin receptors. In this context, our study lays a foundation for future research to examine enteropathy related to dystrophin deficiency.