Synthesis and Evaluation of a Series of 1,3,4-Thiadiazole Derivatives as Potential Anticancer Agents
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, cilt.18, sa.11, ss.1606-1616, 2018 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 18 Sayı: 11
- Basım Tarihi: 2018
- Doi Numarası: 10.2174/1871520618666180509111351
- Dergi Adı: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1606-1616
- Anahtar Kelimeler: Benzothiazole, thiadiazole, anticancer activity, apoptosis, DNA synthesis, human hepatocellular carcinoma, IN-VITRO EVALUATION, BIOLOGICAL EVALUATION, DESIGN, INHIBITORS, 1,3,4-OXADIAZOLE, BENZOTHIAZOLES, CYTOTOXICITY, ANTIFUNGAL, MOLECULES, PROGRESS
- Bilecik Şeyh Edebali Üniversitesi Adresli: Hayır
Özet
Background and Methods: In an attempt to develop potent antitumor agents, the synthesis of a series of N-(6-substituted benzothiazol-2-yl)-2-1(5-(arylamino)-1,3,4-thiadiazol-2-yl)thiolacetamides (1-14) was described and their cytotoxic effects on A549 human lung adenocarcinoma, MCF-7 human breast adenocarcinoma, HepG2 human hepatocellular carcinoma and NIH/3T3 mouse embryonic fibroblast cell lines were investigated using Mil' assay.