Synthesis and Evaluation of a Series of 1,3,4-Thiadiazole Derivatives as Potential Anticancer Agents

ALTINTOP M. D., SEVER B., ÖZDEMİR A., ILGIN S., ATLI EKLİOĞLU Ö., Turan-Zitouni G., ...More

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, vol.18, no.11, pp.1606-1616, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 11
  • Publication Date: 2018
  • Doi Number: 10.2174/1871520618666180509111351
  • Journal Name: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1606-1616
  • Keywords: Benzothiazole, thiadiazole, anticancer activity, apoptosis, DNA synthesis, human hepatocellular carcinoma, IN-VITRO EVALUATION, BIOLOGICAL EVALUATION, DESIGN, INHIBITORS, 1,3,4-OXADIAZOLE, BENZOTHIAZOLES, CYTOTOXICITY, ANTIFUNGAL, MOLECULES, PROGRESS
  • Bilecik Şeyh Edebali University Affiliated: No

Abstract

Background and Methods: In an attempt to develop potent antitumor agents, the synthesis of a series of N-(6-substituted benzothiazol-2-yl)-2-1(5-(arylamino)-1,3,4-thiadiazol-2-yl)thiolacetamides (1-14) was described and their cytotoxic effects on A549 human lung adenocarcinoma, MCF-7 human breast adenocarcinoma, HepG2 human hepatocellular carcinoma and NIH/3T3 mouse embryonic fibroblast cell lines were investigated using Mil' assay.