Synthesis and antimicrobial activity evaluation of new hydrazide derivatives Yeni Hidrazid Türevlerinin Sentezi ve Bunların Antimikrobiyal Aktivitelerinin Deǧerlendirilmesi
Turkish Journal of Pharmaceutical Sciences, cilt.8, sa.3, ss.199-206, 2011 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 8 Sayı: 3
- Basım Tarihi: 2011
- Dergi Adı: Turkish Journal of Pharmaceutical Sciences
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.199-206
- Anahtar Kelimeler: 5,6,7,8-tetrahydro-2-naphthol, Aldehydes, Antimicrobial activity, Hydrazide
- Bilecik Şeyh Edebali Üniversitesi Adresli: Hayır
Özet
The enhancement of bacterial resistance of pathogens to currently available antibiotics constitutes a serious public health threat. Therefore, intensive efforts are underway worldwide to develop new antimicrobial agents. To identify compounds with a potent antimicrobial profile, we designed and synthesized some hydrazide derivatives 1a-e. The chemical structures of the compounds were elucidated by elemental analyses, IR, 1H-NMR, 13C-NMR and FAB+-MS spectral data. Their antimicrobial activities against to E. coli (NRRL B-3008), Staphylococcus aureus (ATCC 6538), Pseudomonas aeruginosa (ATCC 27853), Proteus vulgaris (NRRL B-123), Salmonella typhimurium (ATCC 13311), Methicillin-resistant Staphylococcus aureus (MRSA) (clinic isolate), Candida albicans (NRRL Y-12983) and Candida parapsilosis (NRRL Y-12696) were investigated. The results showed that all of the tested compounds were inactive against the test organism.