Inheritance of pericentric inversion in chromosome 7 through the three progenies and a newborn with congenital hydronephrosis diagnosed prenatally by fetal urine sampling
Fertility and Sterility, cilt.89, sa.1, 2008 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 89 Sayı: 1
- Basım Tarihi: 2008
- Doi Numarası: 10.1016/j.fertnstert.2007.02.030
- Dergi Adı: Fertility and Sterility
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Anahtar Kelimeler: Congenital hydronephrosis, cytogenetic diagnosis, fetal urine, pericentric inversion 7, recurrent miscarriages
- Bilecik Şeyh Edebali Üniversitesi Adresli: Hayır
Özet
Objective: To report the inheritance of a pericentric inversion in chromosome 7 through the three progenies, congenital hydronephrosis, and recurrent miscarriages in an extended family. Design: Case report. Setting: Medical Faculty of Cukurova University in Turkey. Patient(s): Referred by obstetrics and gynecology clinic. Intervention(s): Fetal urine and lymphocytic karyotype. Main Outcome Measure(s): Chromosomal analysis from fetal urine and peripheral blood lymphocytes were performed according to standard cytogenetic methods. Result(s): We assessed an extended family in which a large pericentric inversion in chromosome 7 is segregating; one of the three progenies with the karyotype 46,XY,inv(7)(p22;q22) was heterozygote for the inversion and presented with congenital hydronephrosis. His mother, mother's brother, grandfather, grandfather's brother, and his daughter were similar for the inversion. Conclusion(s): This case describes the further molecular characterization of these breakpoints on the short or long arm of chromosome 7(p22-q22). The inv(7) is also associated with fetal wastage and may be playing a role in the etiology of the family's miscarriages. These findings can be used in clinical genetics and may be an effective tool for reproductive guidance and genetic counseling. © 2008 American Society for Reproductive Medicine.