The synthesis of some triazolylphenothiazine derivatives and their antidepressant and anxiolytic activities
Bollettino Chimico Farmaceutico, cilt.141, sa.3, ss.192-196, 2002 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 141 Sayı: 3
- Basım Tarihi: 2002
- Dergi Adı: Bollettino Chimico Farmaceutico
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.192-196
- Anahtar Kelimeler: 1,2,4-triazole derivatives, 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine derivatives, Antidepressant and anxiolytic activity, Phenothiazine derivatives
- Bilecik Şeyh Edebali Üniversitesi Adresli: Hayır
Özet
10-[2-(4-Amino-5-mercapto-1,2,4-triazol-3-yl)ethyl]phenothiazine was prepared starting from 3-(10-phenothiaziniyl)propionic acid. This new triazole was employed in the synthesis of some Schiff bases and N-bridged heterocycles. All the newly synthesized compounds were characterized by analytical, IR, 1H-NMR and MASS Spectral studies. Some of the newly synthesized compounds were screened for their antidepressant and anxiolytic activities.