Akademik Veri Yönetim Sistemi
Journal of Updates in Cardiovascular Medicine, cilt.8, sa.4, ss.180-185, 2020 (Hakemli Dergi)
Objectives:
Noncompaction cardiomyopathy (NCCM) is a rare genetic form of cardiomyopathy. Morphologically, it consists of a thickened two-layer myocardial structure (noncompacted-compacted layers.). In NCCM, especially in highly symptomatic cases, abnormal basal electrocardiographic (ECG) patterns can be observed at all stages of atrial and/or ventricular depolarization and repolarization. In recent studies, it has been shown that increased QT duration, fragmented QRS pattern, increased spatial QRS-T angle could be predictive concerning ventricular arrhythmias in NCCM. We aimed to show the relationship (if any) between the parameters related to ventricular depolarization and repolarization, which are QT variability/dispersion (QTd), TPe, TPe/QT ratio, “the index of Cardiac-Electrophysiologic Balance (iCEB)” and NCCM.
Materials and Methods:
Thirty NCCM patients and 31 healthy volunteers were included in this cross-sectional, case-control study. ECG parameters related to ventricular polarization were evaluated for all participants.
Results:
In our study, we observed that TPe, corrected TPe (cTPe), TPe/QT, TPe/corrected QT (cQT) and cTPe/cQT values were significantly lower in NCCM patients compared to controls (all p values <0.005). QTd and corrected QTd (cQTd) values are also relatively low in NCCM (p>0.05).
Conclusion:
We found a significant relationship between NCCM and TPe, cTPe, TPe/QT, TPe/cQT, cTPe/cQT parameters. It can be thought that our study contributed to the literature with the present findings and it may also be a guide for clinical trials to investigate the relationship of these parameters with ventricular arrhythmias in NCCM.