Synthesis of new derivatives containing pyridine, investigation of MAO inhibitory activities and molecular docking studies

OSMANİYE D., SAĞLIK B. N., LEVENT S., ÖZKAY Y., KAPLANCIKLI Z. A., TURAN G.

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, cilt.77, sa.11-12, ss.509-517, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 77 Sayı: 11-12
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1515/znc-2022-0075
  • Dergi Adı: ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.509-517
  • Anahtar Kelimeler: molecular docking, pyridine, selective MAO-B inhibitor, thiazolyl-hydrazone, MONOAMINE-OXIDASE-A, BIOLOGICAL EVALUATION, THIAZOLE DERIVATIVES, RAT-BRAIN, DESIGN, IDENTIFICATION, HYDRAZONE, ALANINE, AMINES
  • Bilecik Şeyh Edebali Üniversitesi Adresli: Hayır

Özet

In this study, novel pyridine-containing thiazolyl hydrazone derivatives were synthesized. Structure determinations of the compounds were performed using H-1 NMR, C-13 NMR and HRMS techniques. The biological activities of the compounds were evaluated against MAO enzymes by in vitro fluorometric method. As a result of activity studies, compound 3a showed selective inhibitory activity against MAO-B enzyme with IC50 = 0.088 + 0.003 mu M. The selectivity index of this compound is greater than 1136. Molecular docking studies were carried out using 2V5Z crystal. It has been observed that docking studies and activity studies are in harmony.