PARP1 (poly(ADP-ribose) polymerase 1)

TUNÇER S., Kavak K.

Atlas of Genetics and Cytogenetics in Oncology and Haematology, sa.8, ss.300-312, 2020 (Scopus) identifier

  • Yayın Türü: Makale / Derleme
  • Basım Tarihi: 2020
  • Doi Numarası: 10.4267/2042/70775
  • Dergi Adı: Atlas of Genetics and Cytogenetics in Oncology and Haematology
  • Derginin Tarandığı İndeksler: Scopus, EMBASE
  • Sayfa Sayıları: ss.300-312
  • Anahtar Kelimeler: Cancer, DNA repair, Inflammation, Neurodegenerative diseases, PARylation, Viral infections
  • Bilecik Şeyh Edebali Üniversitesi Adresli: Evet

Özet

© 2020 Atlas of Genetics and Cytogenetics in Oncology and Haematology.PARP1 (poly(ADP-ribose) polymerase 1) is a nuclear protein involved in the regulation of various biological processes including apoptosis, DNA repair for the maintenance of genome integrity, epigenetic marking of chromatin, assembly of higher-order chromatin structures, transcriptional activation, differentiation, proliferation, and cell cycle. Particularly, due to its decisive role in several DNA repair pathways, the inhibition of PARP1 has emerged as a prominent therapeutic option in cancer treatment, by improving the efficiency of chemotherapeutics or radiation therapy.