Some urea and thiourea derivatives bearing 1,2,4-triazole ring and their anti-acetylcholinesterase activities

Abu Mohsen, Usama; KAYMAKÇIOĞLU, BEDİA; Celen, Ahmet; KAPLANCIKLI, ZAFER

doi:10.5455/musbed.20140326030221

Some urea and thiourea derivatives bearing 1,2,4-triazole ring and their anti-acetylcholinesterase activities

Abu Mohsen U., KAYMAKÇIOĞLU B., Celen A. O., KAPLANCIKLI Z. A.

CLINICAL AND EXPERIMENTAL HEALTH SCIENCES, cilt.4, sa.2, ss.85-89, 2014 (ESCI)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 4 Sayı: 2
Basım Tarihi: 2014
Doi Numarası: 10.5455/musbed.20140326030221
Dergi Adı: CLINICAL AND EXPERIMENTAL HEALTH SCIENCES
Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
Sayfa Sayıları: ss.85-89
Anahtar Kelimeler: Urea, thiourea, 1,2,4-triazole, anti-acetylcholinesterase activity, CHOLINERGIC HYPOTHESIS, ALZHEIMERS-DISEASE, ACETYLCHOLINESTERASE, INHIBITION, DESIGN, DRUG
Bilecik Şeyh Edebali Üniversitesi Adresli: Hayır

Özet

Objective: Twenty different urea and thiourea derivatives were synthesized and evaluated for their ability to inhibit acetylcholinesterase (AChE) using a modification of Ellman's spectrophotometric method.