Spectroscopic ellipsometry-based aptasensor platform for bisphenol a detection

ŞAHİN S., Üstündağ Z., ÇAĞLAYAN M. O.

Talanta, cilt.253, 2023 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 253
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1016/j.talanta.2022.123885
  • Dergi Adı: Talanta
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, L'Année philologique, Aerospace Database, Analytical Abstracts, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, Communication Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Metadex, Pollution Abstracts, Veterinary Science Database, Civil Engineering Abstracts
  • Anahtar Kelimeler: Aptasensor, Biosensors, Bisphenol a, Spectroscopic ellipsometry
  • Bilecik Şeyh Edebali Üniversitesi Adresli: Evet

Özet

© 2022 Elsevier B.V.Endocrine-disrupting chemicals (EDC) are pollutants that alter the function of the endocrine system by interfering with hormone biosynthesis, metabolism, or action. In this study, a spectroscopic ellipsometry platform is proposed using aptamers for the sensitive and selective detection of an EDC, 2,2-Bis(4-hydroxyphenyl)propane (Bisphenol A, BPA). Two different BPA-specific aptamers (Anti-BPA1 and Anti-BPA2) were immobilized to silicon wafer chips by the layer-by-layer self-assembly, a detection limit of 215 pM and 36 pM was obtained using the ellipsometric method for Anti-BPA1 and Anti-BPA2, respectively. Sensor specificity was tested with 2,2-Bis(4-hydroxyphenyl)butane and a maximum RSD of 3.8% was obtained. It has been reported that both aptasensors based on spectroscopic ellipsometry exhibit adequate analytical performance.