Synthesis and Evaluation of A New Series of Thiazole Derivatives as Potential Antitumor Agents and MMP Inhibitors

KAPLANCIKLI Z. A., ALTINTOP M. D., ATLI EKLİOĞLU Ö., SEVER B., BAYSAL M., TEMEL H. E., ...More

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, vol.17, no.5, pp.674-681, 2017 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 17 Issue: 5
  • Publication Date: 2017
  • Doi Number: 10.2174/1871520616666160802113620
  • Journal Name: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.674-681
  • Keywords: Thiazole, triazole, oxadiazole, anticancer activity, matrix metalloproteinase, MATRIX-METALLOPROTEINASE INHIBITORS, HUMAN BREAST-CANCER, OF-THE-LITERATURE, ANTICANCER AGENTS, IN-VITRO, PYRAZOLINE DERIVATIVES, HYDRAZONE DERIVATIVES, BIOLOGICAL EVALUATION, COLORECTAL-CANCER, CELL INVASION
  • Bilecik Şeyh Edebali University Affiliated: No

Abstract

Background: In recent years, the relationship between overexpression of matrix metalloproteinases ( MMPs) and tumor invasion/metastasis has prompted researchers to develop MMP inhibitors as anticancer drugs.