Antinociceptive activities of some triazole and pyrazoline moieties-bearing compounds

DEMİR ÖZKAY Ü., CAN Ö. D., KAPLANCIKLI Z. A.

MEDICINAL CHEMISTRY RESEARCH, vol.21, no.7, pp.1056-1061, 2012 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 7
  • Publication Date: 2012
  • Doi Number: 10.1007/s00044-011-9619-z
  • Journal Name: MEDICINAL CHEMISTRY RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1056-1061
  • Keywords: Triazole, Pyrazoline, Analgesia, Hot-plate, Tail-clip, Formalin test, Activity cage, ANALGESIC ACTIVITY, ANTIINFLAMMATORY ACTIVITIES, PHARMACOLOGICAL EVALUATION, METHANOLIC EXTRACT, FORMALIN TEST, MICE, DERIVATIVES, AGENTS, 1-ACYLTHIOSEMICARBAZIDES, ANTIDEPRESSANTS
  • Bilecik Şeyh Edebali University Affiliated: No

Abstract

This study was designed to evaluate the potential antinociceptive activities of some triazole-pyrazoline derivatives. All of the test compounds (100 mg/kg) increased the reaction times of mice in hotplate and tail-clip tests and decreased the total licking times of animals at both phases of formalin test. Compounds 3a, 3b, and 3c were more potent than the others in all nociception tests. None of the test compounds changed the spontaneous locomotor activities of animals. The findings obtained in this study supported the results of previous studies reporting the analgesic activities of triazole and/or pyrazoline derivatives.