Synthesis and biological evaluation of some new amide moiety bearing quinoxaline derivatives as antimicrobial agents

Abu Mohsen U., YURTTAŞ L., Acar U., ÖZKAY Y., Kaplacikli Z., Karaca Gencer H., ...Daha Fazla

Drug Research, cilt.65, sa.5, ss.266-271, 2015 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 65 Sayı: 5
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1055/s-0034-1377004
  • Dergi Adı: Drug Research
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Sayfa Sayıları: ss.266-271
  • Anahtar Kelimeler: quinoxaline, amide, antimicrobial activity, ANTI-BACTERIAL, ANTIFUNGAL
  • Bilecik Şeyh Edebali Üniversitesi Adresli: Hayır

Özet

© 2015 by Thieme Medical Publishers, Inc.In this study, we aimed to synthesize some new quinoxaline derivatives bearing amide moiety and to evaluate their antimicrobial activity. A set of 16 novel compounds of N-[2,3-bis(4-methoxy/methylphenyl)quinoxalin-6-yl]-substituted benzamide derivatives were synthesized by reacting 2,3-bis(4-methoxyphenyl)-6-aminoquinoxaline or 2,3-bis(4-methylphenyl)-6-aminoquinoxaline with benzoyl chloride derivatives in tetrahydrofuran and investigated for their antimicrobial activity. The structures of the obtained final compounds were confirmed by spectral data (IR, 1H-NMR, 13C-NMR and MS). The antimicrobial activity of the compounds were determined by using the microbroth dilution method. Antimicrobial activity results revealed that synthesized compounds exhibited remarkable activity against Candida krusei (ATCC 6258) and Candida parapsilosis (ATCC 22019).