Synthesis and antimicrobial activity of some 2-(benzo[d]oxazol/benzo[d]imidazol-2-ylthio)-N-(9H-fluoren-9-yl)acetamide derivatives
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, vol.182, no.3, pp.639-646, 2007 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 182 Issue: 3
- Publication Date: 2007
- Doi Number: 10.1080/10426500601047016
- Journal Name: PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
- Page Numbers: pp.639-646
- Keywords: antimicrobial activity, benzo[d]imidazole, benzo[d]oxazole, fluorene, ANTIBIOTIC-RESISTANCE, THERAPY
- Bilecik Şeyh Edebali University Affiliated: No
Abstract
Some 2-(benzo[d]oxazol/benzo[d]imidazol-2-ylthio)-N-(9H-fluoren-9-yl)acetamide derivatives were synthesized by reacting 9-(chloroacetylamino)fluorene with benzo[d]oxazol/benzo[d]imidazol-2-thiole in acetone in the presence of K2CO3. Chemical structures of the compounds were elucidated by H-1 NMR spectroscopy and FAB(+) mass spectrometty. Their antimicrobial activities against Micrococcus luteus (NRLL B-4375), Bacillus cereus (NRRL B-3711), Proteus vulgaris (NRRL B-123), Salmonella typhimurium (NRRL B-4420), Staphylococcus aureus (NRRL B-767), Escherichia coli (NRRL B-3704), Candida albicans, and Candida glabrata were investigated, and significant activity was observed.