Synthesis and antimicrobial activity of some 2-(benzo[d]oxazol/benzo[d]imidazol-2-ylthio)-N-(9H-fluoren-9-yl)acetamide derivatives
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, cilt.182, sa.3, ss.639-646, 2007 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 182 Sayı: 3
- Basım Tarihi: 2007
- Doi Numarası: 10.1080/10426500601047016
- Dergi Adı: PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
- Sayfa Sayıları: ss.639-646
- Anahtar Kelimeler: antimicrobial activity, benzo[d]imidazole, benzo[d]oxazole, fluorene, ANTIBIOTIC-RESISTANCE, THERAPY
- Bilecik Şeyh Edebali Üniversitesi Adresli: Hayır
Özet
Some 2-(benzo[d]oxazol/benzo[d]imidazol-2-ylthio)-N-(9H-fluoren-9-yl)acetamide derivatives were synthesized by reacting 9-(chloroacetylamino)fluorene with benzo[d]oxazol/benzo[d]imidazol-2-thiole in acetone in the presence of K2CO3. Chemical structures of the compounds were elucidated by H-1 NMR spectroscopy and FAB(+) mass spectrometty. Their antimicrobial activities against Micrococcus luteus (NRLL B-4375), Bacillus cereus (NRRL B-3711), Proteus vulgaris (NRRL B-123), Salmonella typhimurium (NRRL B-4420), Staphylococcus aureus (NRRL B-767), Escherichia coli (NRRL B-3704), Candida albicans, and Candida glabrata were investigated, and significant activity was observed.