Synthesis and antimicrobial activity of some 2-(benzo[d]oxazol/benzo[d]imidazol-2-ylthio)-N-(9H-fluoren-9-yl)acetamide derivatives

Turan-Zitouni G., KAPLANCIKLI Z. A., ÖZDEMİR A., Revial G., Guven K.

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, vol.182, no.3, pp.639-646, 2007 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 182 Issue: 3
  • Publication Date: 2007
  • Doi Number: 10.1080/10426500601047016
  • Journal Name: PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
  • Page Numbers: pp.639-646
  • Keywords: antimicrobial activity, benzo[d]imidazole, benzo[d]oxazole, fluorene, ANTIBIOTIC-RESISTANCE, THERAPY
  • Bilecik Şeyh Edebali University Affiliated: No

Abstract

Some 2-(benzo[d]oxazol/benzo[d]imidazol-2-ylthio)-N-(9H-fluoren-9-yl)acetamide derivatives were synthesized by reacting 9-(chloroacetylamino)fluorene with benzo[d]oxazol/benzo[d]imidazol-2-thiole in acetone in the presence of K2CO3. Chemical structures of the compounds were elucidated by H-1 NMR spectroscopy and FAB(+) mass spectrometty. Their antimicrobial activities against Micrococcus luteus (NRLL B-4375), Bacillus cereus (NRRL B-3711), Proteus vulgaris (NRRL B-123), Salmonella typhimurium (NRRL B-4420), Staphylococcus aureus (NRRL B-767), Escherichia coli (NRRL B-3704), Candida albicans, and Candida glabrata were investigated, and significant activity was observed.