Which Polymorphism Is The Distinguishing Factor For Fitness Athletes: The Ace Indel or Actn3 rs1815739?

Eroğlu O., Zileli R., Nalbant M. A., Polat T., Yılmaz Ö. Ö., Aslan B. T., ...More

Journal of Basic and Clinical Health Sciences, vol.8, no.2, pp.319-326, 2024 (ESCI, TRDizin)

Abstract

Purpose: The purpose of this research was to investigate the occurrence of ACE InDel and ACTN3 rs1815739 in sub-elite fitness athletes and to determine which gene is distinctive by comparing genotype and allele frequencies with sedentary individuals. Material and Methods: Forty-one sub-elite fitness athletes and the same number of the sedentary volunteers participated in the study. Genetic analyzes of the athletes were determined using molecular-based methods such as DNA isolation from peripheral blood samples by using a commercial kit and genotyping with real-time polymerase chain reaction (Real-Time PCR), and conventional polymerase chain reaction (PCR). The Chi-Square test was used to compare the genotype distribution and I, D, C, and T allele frequencies of ACE InDel and ACTN3 rs1815739 polymorphisms for statistical significance. Results: No statistical difference was found for ACE I/D polymorphism in terms of both genotype distribution (p=0.4438). A comparison of sub-elite fitness athletes and control groups showed that the ACTN3 rs1815739 polymorphism had a statistically significant difference in terms of genotype distribution (p=0.0313). Conclusion: In conclusion, we suggest that the ACTN3 rs1815739 polymorphism is more effective than the ACE InDel polymorphism in fitness athletes.