Synthesis and anticandidal evaluation of new benzothiazole derivatives with hydrazone moiety

Creative Commons License

YURTTAŞ L., KAPLANCIKLI Z. A., Goger G., DEMİRCİ F.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol.31, no.5, pp.714-720, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 5
  • Publication Date: 2016
  • Doi Number: 10.3109/14756366.2015.1060481
  • Journal Name: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
  • Page Numbers: pp.714-720
  • Keywords: 2-Mercaptobenzothiazole, anticandidal, antifungal, hydrazone, ANTIMICROBIAL ACTIVITY, THIAZOLE DERIVATIVES, ANTIFUNGAL ACTIVITY, CYTOTOXICITY, INFECTIONS
  • Bilecik Şeyh Edebali University Affiliated: No

Abstract

In this study, we have performed the synthesis of new N-(arylidene)-4-[(benzothiazol-2-yl)thio]butanoylhydrazide derivatives (3a-s) bearing azole moiety and hydrazone group in a lipophilic structural framework. The target compounds were prepared by a three step synthetic procedure starting from 2-mercaptobenzothiazole. The structures of the target compounds were elucidated by IR, H-1 NMR, C-13 NMR spectra and elemental analysis. The antifungal activity of the obtained compounds has been determined against a number of clinic and fluconazole-resistant Candida strains by using microdilution method. Compounds (3a-3s) exhibited anticandidal activity in different ratios varying between the range of MIC: 50 and 200 mu g/mL.