Asprosin and meteorin-like protein immunoreactivity in invasive ductal breast carcinoma stages

Akkus G., Koyuturk L. C., Yilmaz M., Hancer S., Ozercan I. H., Kuloglu T.

Tissue and Cell, vol.77, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 77
  • Publication Date: 2022
  • Doi Number: 10.1016/j.tice.2022.101855
  • Journal Name: Tissue and Cell
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Keywords: Asprosin, Histopathology, Invasive ductal breast cancer, Meteorin-like protein
  • Bilecik Şeyh Edebali University Affiliated: No

Abstract

Aim: The study aimed to investigate asprosin (ASP) and meteorin-like (METRNL) protein immunoreactivity in invasive ductal breast cancer. Materials and methods: Overall, 60 cases of invasive ductal breast cancer (20 cases each of Grade 1, 2 and 3) were evaluated in addition to 20 normal breast tissues obtained from the Pathology Department Archive. ASP and METRNL expressions were assessed using immunohistochemical staining and visualised under a light microscope. Results: There was a significant difference in ASP and METRNL immunoreactivity among all the groups included in the study (p < 0.001). Cancer tissues with Grade 1, 2 and 3 showed a significant increase in ASP and METRNL immunoreactivity compared with the control group; however, no significant difference was noted among the cancer tissues with Grade 1, 2 and 3. Conclusions: ASP and METRNL immunoreactivity increased at the cellular level in invasive ductal breast cancer, but there was no difference in immunoreactivity among the breast cancer grades.