Synthesis and antimicrobial activity of benzimidazole-based acetamide derivatives Benzimidazol taşıyan asetamit türevlerinin sentezi ve antimikrobiyal etkileri

ALTINTOP M. D., Abu Mohsen U., ÖZKAY Y., DEMİREL R., KAPLANCIKLI Z. A.

Turkish Journal of Pharmaceutical Sciences, cilt.12, sa.1, ss.29-38, 2015 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12 Sayı: 1
  • Basım Tarihi: 2015
  • Dergi Adı: Turkish Journal of Pharmaceutical Sciences
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.29-38
  • Anahtar Kelimeler: Amide, Antimicrobial activity, Benzimidazole
  • Bilecik Şeyh Edebali Üniversitesi Adresli: Hayır

Özet

© 2015, Turkish Pharmacists Association. All rights reserved.In the current work, new benzimidazole-based acetamide derivatives (2a-u) were synthesized and screened for their in vitro antimicrobial activity. Among these derivatives, compounds 2b-2g were found to be the most promising antibacterial agents against Pseudomonas aeruginosa. These compounds and streptomycin exhibited the same level of antibacterial activity with a MIC value of 125 μg/mL. Compounds 2p, 2s, 2t and 2u were the most potent antifungal derivatives against Candida krusei with a MIC value of 125 μg/mL when compared with ketoconazole (MIC= 62.5 μg/mL). Compounds 2s and 2u also exhibited the highest inhibitory activity against Fusarium solani with a MIC value of 125 μg/mL, whereas ketoconazole showed its antifungal activity with a MIC value of 62.5 μg/mL.