Scientia Iranica, vol.24, no.6, pp.3081-3086, 2017 (SCI-Expanded)
Artificial flazo dyes are widely used as coloring agents for foodstuffs, drugs, and cosmetics. In this study, the toxic effects of four different synthetic food dyes (Ponceau 4R, Sunset Yellow, Amaranth, Tartrazine) on 72 - 4h larvae of Oregon (R) wild type of Drosophila melanogaster were investigated. In addition, depending on chronic feeding, the life span of the ies was determined. For this purpose, six different concentrations of food dyes (5, 10, 15, 20, 25, and 30 mg mL-1) were selected by preliminary studies to determine LD100 values. The e ects of the food dyes on longevity were studied separately in female and male populations. It was determined that the maximum mean life span of the female and male D. melanogaster populations decreased with increasing concentrations of food dyes. Based on the results obtained from the larval mortality and life span experiments, the order of toxicity for food dyes was: Tartrazine > Amaranth > Sunset Yellow > Ponceau 4R.