Akademik Veri Yönetim Sistemi
Andrologia, cilt.50, sa.10, 2018 (SCI-Expanded)
Testicular torsion is a surgical emergency and the testicular salvage rate through surgical detorsion ranges from 42% to 88%. However, it is not known to what extent spermatogenic function is preserved in these testes. The purpose of the study was to demonstrate the prognostic value of thiol/disulphide homeostasis in rats for testicular ischaemia and ischaemia–reperfusion injury during early and late stages. A total of 21 Wistar albino rats were randomly divided into three groups. The 4 and 8-hr T/D (torsion/detorsion) groups were subjected to left testicular torsion by twisting the testes by 720° counterclockwise direction. The 2 cc venous blood samples were also collected from the 4 and 8-hr T/D groups after 4 and 8 hr respectively. It was determined that the native thiol, total thiol and disulphide values of 4 and 8-hr T/D group before detorsion were significantly lower than those of the sham group (p: 0.006; p: 0.003; p: 0.003). In the 8-hr T/D group, there was a positive statistically significant relationship at an 88.3% level between Johnsen's score and total thiol values before detorsion (p: 0.008). Our study showed that thiol/disulphide homeostasis may be a haematologic parameter in predicting testicular ischaemia and histopathologic injury in the testes following ischaemia–reperfusion.