Synthesis of new benzothiazole derivatives bearing thiadiazole as monoamine oxidase inhibitors

ACAR ÇEVİK U., OSMANİYE D., SAĞLIK B. N., LEVENT S., KAYA ÇAVUŞOĞLU B., KARADUMAN A. B., ...More

JOURNAL OF HETEROCYCLIC CHEMISTRY, vol.57, no.5, pp.2225-2233, 2020 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 57 Issue: 5
  • Publication Date: 2020
  • Doi Number: 10.1002/jhet.3942
  • Journal Name: JOURNAL OF HETEROCYCLIC CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), Chimica, EMBASE, Index Chemicus (IC)
  • Page Numbers: pp.2225-2233
  • Bilecik Şeyh Edebali University Affiliated: No

Abstract

Monoamine oxidases (MAO) are enzymes that catalyze the oxidative deamination of monoamines such as dopamine, noradrenaline, adrenaline, and serotonin. Recent studies have shown that numerous benzothiazole derivatives exhibit hMAO inhibitory activity in the micromolar concentration range. In this study, a novel series of benzothiazole-thiadiazole (5a-5l) was synthesized and characterized their chemical structures by H-1-NMR, C-13-NMR, and Mass spectroscopy. These compounds were evaluated as inhibitors for types A and B MAO enzymes. Compounds 5f and 5l were the most active derivatives in the series with an IC50 values of 0.107 +/- 0.003 and 0.128 +/- 0.004, respectively. Furthermore, cytotoxicity of compounds 5f and 5l were investigated and found as non-cytotoxic.