New N'-Arylidene-2-[(4-Nitrophenyl) Piperazin-1-yl]Acetohydrazide Derivatives: Synthesis and Anticancer Activity Investigation

YURTTAŞ, LEYLA; KAPLANCIKLI, ZAFER; Gorgulu-Kahyaoglu, Sennur

doi:10.2174/1570180814666161207163450

New N'-Arylidene-2-[(4-Nitrophenyl) Piperazin-1-yl]Acetohydrazide Derivatives: Synthesis and Anticancer Activity Investigation

YURTTAŞ L., KAPLANCIKLI Z. A., Gorgulu-Kahyaoglu S.

LETTERS IN DRUG DESIGN & DISCOVERY, cilt.14, sa.8, ss.910-917, 2017 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 14 Sayı: 8
Basım Tarihi: 2017
Doi Numarası: 10.2174/1570180814666161207163450
Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.910-917
Anahtar Kelimeler: Antiproliferative, apoptosis, cytotoxicity, hydrazone, piperazine, biological activities, PROCASPASE-ACTIVATING COMPOUND, ANNEXIN-V, BENZIMIDAZOLE DERIVATIVES, BIOLOGICAL EVALUATION, AGENTS
Bilecik Şeyh Edebali Üniversitesi Adresli: Hayır

Özet

Background: Compounds bearing ortho-hydroxy N-acyl hydrazone moiety have been reported with high anticancer activity acting by increasing the enzymatic activity of procaspase-3 in cancer cells and therefore inducing apoptosis in some tumour models.