The association of serum iron parameters with histopathological grade and mast cell density in prostatic adenocarcinoma: A single-center retrospective study
Kuwait Medical Journal, cilt.58, sa.2, ss.121-126, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 58 Sayı: 2
- Basım Tarihi: 2026
- Dergi Adı: Kuwait Medical Journal
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.121-126
- Anahtar Kelimeler: ferritins, iron, mast cells, neoplasm, neoplasm grading
- Bilecik Şeyh Edebali Üniversitesi Adresli: Evet
Özet
Objective: To investigate the association between mast cell density, histopathological grades and prediagnostic serum iron parameters in prostate cancer Design: A retrospective design Settings: Paraffin-embedded tissue blocks were retrieved from the archives of the Department of Pathology at Bilecik Training and Research Hospital, Turkey. Subjects: The study included twenty-four cases of prostate cancer with measured serum iron parameters within a one-year prediagnostic period. Interventions: Serum iron and ferritin levels within one year before biopsies were recorded. Gleason scoring was performed using histochemistry. Mast cells were counted in the intratumoral area of histological sections stained with toluidine blue. Main outcome measures: Statistical analysis of serum iron or ferritin levels and mast cell density was conducted to evaluate their association with grade in terms of prognosis. Results: Among the cases, 62.5% were classified as low grade, while 37.5% were categorized as high grade. Age correlated with grade (P <0.05). High-grade cases exhibited significantly lower serum iron levels and higher serum ferritin levels (P <0.05). A strong negative correlation was observed between serum iron and grade (r=-0.763, P=0.001), while a robust positive correlation existed between serum ferritin levels and grade (r=0.705, P<0.001). However, mast cell density did not significantly differ between groups and did not correlate with age, grade or serum iron parameters (P >0.05). Conclusion: There is no significant association between intratumoral mast cell density and serum iron parameters or prostate cancer grade. However, prediagnostic serum iron parameters, showing a high correlation with grade, could serve as potential prognostic factors in prostate cancer.