Synthesis of Novel 4-(Dimethylaminoalkyl) piperazine-1-carbodithioate Derivatives as Cholinesterase Inhibitors

ACAR ÇEVİK U., LEVENT S., SAĞLIK B. N., ÖZKAY Y., KAPLANCIKLI Z. A.

LETTERS IN DRUG DESIGN & DISCOVERY, vol.14, no.5, pp.528-539, 2017 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 5
  • Publication Date: 2017
  • Doi Number: 10.2174/1570180813666160923105636
  • Journal Name: LETTERS IN DRUG DESIGN & DISCOVERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.528-539
  • Keywords: Piperazine, dithiocarbamate, acetylcholinesterase, butyrylcholinesterase, enzyme, ALZHEIMERS-DISEASE, ACETYLCHOLINESTERASE INHIBITORS, N-BENZYLPIPERIDINE, PIPERAZINE DERIVATIVES, BIOLOGICAL EVALUATION, MOLECULAR DOCKING, DUAL INHIBITORS, DESIGN, PIPERIDINE, AGENTS
  • Bilecik Şeyh Edebali University Affiliated: No

Abstract

Background: Carbamate compounds have attracted a great deal of interest in medicinal chemistry due to their inhibition potential against cholinesterase enzymes.