Synthesis of Novel 4-(Dimethylaminoalkyl) piperazine-1-carbodithioate Derivatives as Cholinesterase Inhibitors

ACAR ÇEVİK, ULVİYE; LEVENT, SERKAN; SAĞLIK, BEGÜM; ÖZKAY, YUSUF; KAPLANCIKLI, ZAFER

doi:10.2174/1570180813666160923105636

Synthesis of Novel 4-(Dimethylaminoalkyl) piperazine-1-carbodithioate Derivatives as Cholinesterase Inhibitors

ACAR ÇEVİK U., LEVENT S., SAĞLIK B. N., ÖZKAY Y., KAPLANCIKLI Z. A.

LETTERS IN DRUG DESIGN & DISCOVERY, cilt.14, sa.5, ss.528-539, 2017 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 14 Sayı: 5
Basım Tarihi: 2017
Doi Numarası: 10.2174/1570180813666160923105636
Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.528-539
Anahtar Kelimeler: Piperazine, dithiocarbamate, acetylcholinesterase, butyrylcholinesterase, enzyme, ALZHEIMERS-DISEASE, ACETYLCHOLINESTERASE INHIBITORS, N-BENZYLPIPERIDINE, PIPERAZINE DERIVATIVES, BIOLOGICAL EVALUATION, MOLECULAR DOCKING, DUAL INHIBITORS, DESIGN, PIPERIDINE, AGENTS
Bilecik Şeyh Edebali Üniversitesi Adresli: Hayır

Özet

Background: Carbamate compounds have attracted a great deal of interest in medicinal chemistry due to their inhibition potential against cholinesterase enzymes.