Akademik Veri Yönetim Sistemi
Bilecik Şeyh Edebali Üniversitesi Fen Bilimleri Dergisi, cilt.6, sa.1a, ss.213-221, 2019 (Hakemli Dergi)
In the last decade, particular sphingolipids have become renowned for their participation in cellmembrane functions and signaling proceedings that regulate a wide array of cellular manners. Ceramide is amajor molecule of sphingolipids metabolism. It plays vital roles in mediating the major cellular functions suchas cell differentiation, cell-to-cell communication, apoptosis, and proliferation. Recent studies have shown thatceramide metabolism and their metabolic enzymes take important role during migration and cell mobility process.However, the molecular mechanism of sphingolipids involved is unknown. Our efforts in this study, which are servingmechanistically the understanding of ceramide, will be shade some light on this unknown. In this work, particularly,we looked at the effect of ceramide syntheses on migration ability of UM-SCC-22A head and neck squamouscarcinoma cells. Briefly, we identified that alterations in ceramide metabolism by pharmacological inhibitorfumonisin B1, reducing bioactive ceramides, results in activation of the TGF-ß receptor type I and II (TßRI/II) cellsurface localization and, leading to increased cell migration/invasion in UM-SCC-22A head and neck squamouscarcinoma cells. On the other hand, primary cilia length in UM-SCC-22A cells did not changed by decreasedceramide amount. Thus, these data reveal that ceramide synthases/ceramide is a novel factor that regulates TßRI/II tothe primary cilium, controlling cell migration and cancer metastasis.