Research Information System
Journal of Pure and Applied Microbiology, vol.7, no.4, pp.2747-2756, 2013 (SCI-Expanded)
This study was conducted to find new chemical substances that are highly effective on selected microorganisms from among eight Cu(II) pyrazine-2,3-dicarboxyIate complexes, which have been previously synthesized and characterized. The MIC value of the [Cu(pzdc)(phen)2] 5.5H 2O complex (8) was determined to be in the range of 15-40 μg/ml for all bacteria (except the clinical isolate Pseudomonas aeruginosa). However, the minimum microbiocidal concentrations (MMC) (30-200 μg/ml) were determined to be much higher than the MIC values. In time-kill assays, all the bacteria were fully finished after 120 minutes at 18 μg/ml and after 240 minutes at 4.5 /μg/ml from 5.54 log. the initial number of bacteria at 37 °C in the lake water. However, all the bacteria were not fully inhibited even at 18 μg/ml at 10 °C. The same effect was not seen on Candida albicans in spite of the low MIC value (25 μg/ml). [Cu(pzdc)(phen)2] 5.5H 2O complex has broad-spectrum biostatic activity against microorganisms at the MIC values. The mechanism of action is not yet clear.