Synthesis and study of antibacterial and antifungal activities of novel 2-[[(benzoxazole/benzimidazole-2-yl)sulfanyl] acetylamino]thiazoles

KAPLANCIKLI Z. A., Turan-Zitouni G., Revial G., Guven K.

ARCHIVES OF PHARMACAL RESEARCH, vol.27, no.11, pp.1081-1085, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 11
  • Publication Date: 2004
  • Doi Number: 10.1007/bf02975108
  • Journal Name: ARCHIVES OF PHARMACAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1081-1085
  • Keywords: thiazole, benzoxazole, benzimidazole, antimicrobial activity, ANTIMICROBIAL ACTIVITY, ANTIBIOTIC-RESISTANCE, DERIVATIVES, THERAPY
  • Bilecik Şeyh Edebali University Affiliated: No

Abstract

Several 2-[[(benzoxazole/benzimidazole-2-yl)sulfanyl]acetylamino]thiazoles derivatives were synthesized by reacting 4-substituted-2-(chloroacetylamino)thiazoles with benzoxazole/benzimidazole-2-thioles in acetone and in the presence of K2CO3. The chemical structures of the compounds were elucidated by IR, H-1-NMR, and FAB(+)-MS spectral data. Their antimicrobial activities against Micrococcus luteus (NRLL B-4375), Bacillus cereus (NRRL B-3711), Proteus vulgaris (NRRL B-123), Salmonella typhimurium (NRRL B-4420), Staphylococcus aureus (NRRL B-767), Escherichia coli (NRRL B-3704), Candida albicans and Candida globrata (isolates obtained from Osmangazi Uni. Fac. of Medicine) were investigated and in this investigation, a significant level of activity was illustrated.