Anti-ulcerogenic and cytoprotective effects of saharian (Sidr) honey from Algeria

Djebli N., Mustafa M. R., KESKİN M., KOLAYLI S.

Combinatorial Chemistry and High Throughput Screening, vol.24, no.10, pp.1664-1670, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 10
  • Publication Date: 2021
  • Doi Number: 10.2174/1386207323999201117114008
  • Journal Name: Combinatorial Chemistry and High Throughput Screening
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.1664-1670
  • Keywords: Gastric ulcer, HCl/Ethanol, IL-6, PGE2, Sahara honey, TNF, Ulcer score
  • Bilecik Şeyh Edebali University Affiliated: Yes

Abstract

© 2021 Bentham Science Publishers.Aim and Objective: This study aimed at investigating the gastro-protective effects of Algerian Sahara (Sidr) honey from Apis mellifera intermissa against HCl/Ethanol-induced gastric ulcers in rats. Materials and Methods: Total phenolic content, antioxidant activity and phenolic compounds were determined. Then, three groups of rats (control, HCl/ Ethanol-induced ulcer, and orally administered honey) were used for the determination of gastro-protective effect of Sidr honey. Results: Total phenolic content, total flavonoid content, and DPPH activity of the honey sample were determined as 47.35±3.35 mg GAE/ 100 g, 2.13±0.17 mg QE/ 100 g, and 229.24±0.02 mg/mL, respectively. Oral pretreatment of rats with honey (1.2 g/Kg body weight orally at an interval of 2 days) protected gastric mucosa against HCl/Ethanol-induced damage by decreasing ulcer score, the volume and acidity of gastric juice and increasing pH. Conclusion: These results were confirmed by the histological assessment, which demonstrated a significant gastro-protective activity of Saharian (Sidr) honey against HCl/Ethanol-induced stomach ulcer. Plasma tumor necrosis factor-α, IL-6 and PGE2 were also measured. Sahara honey significantly decreased the plasma TNF-α, PGE2, and IL-6 concentrations.