ALDH1A1 (aldehyde dehydrogenase 1 family member A1)

TUNÇER S., Çamlica R., Yilmaz I.

Atlas of Genetics and Cytogenetics in Oncology and Haematology, cilt.24, sa.3, ss.102-111, 2020 (Scopus) identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 24 Sayı: 3
  • Basım Tarihi: 2020
  • Doi Numarası: 10.4267/2042/70676
  • Dergi Adı: Atlas of Genetics and Cytogenetics in Oncology and Haematology
  • Derginin Tarandığı İndeksler: Scopus, EMBASE
  • Sayfa Sayıları: ss.102-111
  • Anahtar Kelimeler: Alcohol, ALDH1A1, Cancer, Retinaldehyde, Retinoic acid, Retinol, Stem cell
  • Bilecik Şeyh Edebali Üniversitesi Adresli: Evet

Özet

© 2020 Atlas of Genetics and Cytogenetics in Oncology and Haematology.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a member of the ALDH gene superfamily. Aldehyde dehydrogenases (ALDHs) are responsible for the metabolism of aldehydes (exogenous and endogenous) through NAD(P)+-dependent oxidation to their corresponding carboxylic acids or CoA esters. Different biological functions have been attributed to the different ALDH family members. The cytosolic enzyme ALDH1A1 is involved in the catalysis of retinol (vitamin A) metabolite retinaldehyde to retinoic acid (RA). RA acts as a ligand for the nuclear receptors retinoic receptor (RAR) and the retinoid X receptor (RXR) and therefore regulates the transcriptional activity of genes involved in multiple important processes including proliferation, differentiation, and apoptosis.