Novel Analogues of 2-Pyrazoline: Synthesis, Characterization, and Antimycobacterial Evaluation

ÖZDEMİR A., Turan-Zitouni G., KAPLANCIKLI Z. A.

TURKISH JOURNAL OF CHEMISTRY, cilt.32, sa.5, ss.529-538, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 5
  • Basım Tarihi: 2008
  • Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.529-538
  • Anahtar Kelimeler: 2-Pyrazolines, Sodium salts of N,N-disubstituted dithiocarbamoic acids, Antimycobacterial activity, ANTIMICROBIAL ACTIVITY, PYRAZOLINES, DERIVATIVES, KETONES, ESTERS
  • Bilecik Şeyh Edebali Üniversitesi Adresli: Hayır

Özet

Fourteen new 1-[(N, N-disubstitutedthiocarbamoylthio) acetyl]-3-(2-thienyl)-5-aryl-2-pyrazoline derivatives were synthesized by reacting 1-(chloroacetyl)-3-(2-thienyl)-5-aryl-2-pyrazolines and appropriate sodium salts of N, N-disubstituted dithiocarbamoic acids in acetone. The structures of the synthesized compounds were confirmed by UV, IR, H-1-NMR, and FAB(+)-MS spectral data. The compounds were evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv using the BACTEC 460 radiometric system and BACTEC 12B medium. The preliminary results showed that all of the tested compounds were inactive against the test organism.