Synthesis and Antimicrobial Activity of New Pyrimidine-Hydrazones
LETTERS IN DRUG DESIGN & DISCOVERY, cilt.11, sa.1, ss.76-81, 2014 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 11 Sayı: 1
- Basım Tarihi: 2014
- Doi Numarası: 10.2174/15701808113109990037
- Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.76-81
- Anahtar Kelimeler: Pyrimidine, Hydrazone, Antimicrobial activity, DERIVATIVES, AGENTS, RESISTANCE, COMPLEXES
- Bilecik Şeyh Edebali Üniversitesi Adresli: Hayır
Özet
The synthesis of twelve new pyrimidine hydrazone derivatives and subsequent evaluation of their antimicrobial activities were the aims of this present work. The intermediate product 2-[(pyrimidin-2-yl)thio]acetohydrazide was refluxed with different aromatic aldehydes/ketones in ethanol to yield N'-(arylidene)-2-[(pyrimidine-5-yl)thio]acetohydrazide derivatives (3a-l). The structures of the compounds were elucidated by NMR, FTIR, MS, and elemental analyses. Additionally the final compounds (3a-l) were evaluated for their antimicrobial activity using a microdilution method against a panel of pathogenic Gram positive, Gram negative, and fungus strains, i.e. Escherichia coli, Pseudomonas aeruginosa, Salmonella typhimurium, Bacillus cereus, Bacillus subtilis, Serrratia marcescens, Staphylococcus epidermidis, and Candida utilis. Compound N'-(2-pyrilidene)-2-[(pyrimidine-5-yl)thio]acetohydrazide (3a) possessing a 2-pyridyl moiety was found to be the most active (MIC=31.25-250 mu g/mL) derivative toward the tested microorganisms.